|
KMID : 0379520050210010051
|
|
한국독성학회지
2005 Volume.21 No. 1 p.51 ~ p.55
|
|
|
Acute Oral Toxicity of Adventitious Roots Extract Derived from Wild Ginseng in Beagle Dogs
|
|
Song Si-Whan
Yang Deok-Chun
Choung Se-Young
|
|
|
Abstract
|
|
|
|
To investigate the acute toxicity of adventitious roots extract derived from wild ginseng, it was orally administered to beagle dogs with a single dose. In acute toxicity test, three groups (9 beagle dogs of male) were administered with different dosages of adventitious roots extract (prepared by Biopia Corp.) 500 mg/kg (G2), 1,000 mg/kg (G3), 2,000 mg/kg (G4) and one group (G1, 2 beagle dogs of male) were received by only capsule without the extract according to the Regulation on Korea Food and Drug Administration (1999. 12. 22). There were vomitus for a time and mucous stool at the day, and anorexia and mucous stool at the first day in the group of 2,000 mg/kg administration. There were mucous stool in one and anorexia for a while in two beagle dogs at the first day in the 1,000 mg/kg administration. But no death or abnormal clinical sign was observed through the study period. Therefore, the adventitious roots extract derived from wild ginseng is considered not to have the acute toxicity in the beagle dogs. These results suggest that LD/sub 50/ value of the test substance was considered to be more than 2,000 mg/kg in the beagle dogs
|
|
|
KEYWORD
|
|
|
Beagle dogs, Acute toxicity, Adventitious roots, Wild ginseng
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|